UTAR Institutional Repository

The Influence Of Age And Gender On Heart Rate Variability

Ng, Chean Swan (2020) The Influence Of Age And Gender On Heart Rate Variability. Final Year Project, UTAR.

[img]
Preview
PDF
Download (1470Kb) | Preview

    Abstract

    Heart rate variability (HRV) has been recognised as a trait marker of mortality and morbidity vulnerability. However, its predictive value might have limited by the indefinite philosophies behind the physiological factors especially the age-related and gender-dependent changes over the life span. Prior works on HRV based on a comparative small population, were insufficient to define the impacts of age and gender on HRV. In this regard, this study attempted a clarification on the age and gender effects on HRV with a large sample size. A total of 14399 patients of which 7275 men and 7124 women who averagely aged 62.53 ± 17.28 years old were recruited in this study at Central Cardiology Sydney practice within a 10 year period. Gender and aging effects on HRV were evaluated by means of four time-domain HRV measures determined by SDNN, SDANN, SDNN-i and rMSSD which were extracted from 24-hour ambulatory ECG recordings that were routinely performed in subjects using 3- channel electrograph. It has been evidenced that, gender effects on HRV were significant (p < 0.001). All HRV measures were significantly depressed with aging (p < 0.001) except for rMSSD in which, a U-shaped curve was yielded (p < 0.001). The aging effects on all HRV measures were gender-dependent (p < 0.001) except HRV determined by rMSSD (p = 0.631). Overall HRV indexes were found to be statistically higher in male subjects compared to the age-matched female subjects. A linear correlated pattern of decrease with aging was observed in SDNN, SDANN and SDNN-i, whereas rMSSD demonstrated a quadratic term that yielded a U-shaped pattern for both genders. In short, a significant deterioration of cardiac autonomic regulation is common in healthy aging. Men excel women at cardiac autonomic regulation which the former are mainly vagal-modulated whereas the latter are primarily sympathetically-driven. A sudden improvement in the global autonomic regulation in women at the sixth decade could have reflected the substantial role of estrogen during womanhood. A more gradual reduction found in all HRV parameters and a progressive increase of rMSSD at the later age could have attributed to the greater longevity in women.

    Item Type: Final Year Project / Dissertation / Thesis (Final Year Project)
    Subjects: R Medicine > R Medicine (General)
    Divisions: Lee Kong Chian Faculty of Engineering and Science > Bachelor of Engineering (Hons) Biomedical Engineering
    Depositing User: Sg Long Library
    Date Deposited: 18 Aug 2021 20:13
    Last Modified: 18 Aug 2021 20:13
    URI: http://eprints.utar.edu.my/id/eprint/4226

    Actions (login required)

    View Item