Association of traditional Chinese medicine (TCM) body constitution, waist circumference and fasting blood glucose with hnf1a and capn10 polymorphisms

See, Ying Mei (2023) Association of traditional Chinese medicine (TCM) body constitution, waist circumference and fasting blood glucose with hnf1a and capn10 polymorphisms. Final Year Project, UTAR.

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Abstract

Traditional Chinese Medicine Body Constitution (TCM BC) is a classification of individual’s body condition influenced by acquired and inborn factors based on Chinese medicine theory. These factors may disturb and cause Yin and Yang imbalance, leading to increased susceptibility to certain diseases. Metabolic syndrome (MetS) is a group of illnesses caused by dysregulation biochemical pathways. MetS is strongly related to abdominal obesity and diabetes. Susceptibility to MetS may differ according to demographic distribution and BMI. TCM BC leads the foundation for diagnosis, treatment and disease prevention. The relationship between TCM BC with abdominal obesity and diabetes was included in this study. Gene variant can increase risk of MetS. Association of metabolic gene variants with abdominal obesity, diabetes and TCM BC was included in this study. Convenience sampling was used, and 102 subjects were recruited with informed consent in this study. Demographic distribution and COVID-19 history were self-declared by respondents. TCM BC was determined using questionnaire. Waist circumference, fasting blood glucose level and anthropometric measurement were measured. Blood was drawn for DNA extraction to genotype rs735396 and rs2975760. SPSS 26.0 was used for data analysis. The prevalence of abdominal obesity and diabetes iii in this study were 34.31% and 1.96%, respectively. Both studied variants were found significant with minor allele frequency > 0.05. Gender, age, place of origin and anthropometric measurement had significant difference in waist circumference and fasting blood glucose level. There was no significant association between TCM BC and gene variants studied as well as between demographic distribution, anthropometric measurements and COVID-19 history with TCM BC. Association between TCM BC with waist circumference and fasting blood glucose level cannot be ruled out as majority study subjects have either gentleness or combinations of body constitutions. Larger sample size and involvement of population with broader variation are recommended in future study.

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