Chong, Jien Lee (2019) Synthesis, characterization and antioxidant activity of 1,3,4-oxadiazoles incorporating an indole moiety. Final Year Project, UTAR.
Abstract
In this project, an indole ester, carboxyl hydrazide and four new 1,3,4-oxadiazoles derivatives have been successfully synthesized and characterized. The four new 1,3,4-oxadiazoles derivatives were synthesized by the reaction of carboxyl hydrazide and benzoic acid derivatives which being named as JL1, JL2 JL3 and JL4 respectively. The structures of carboxyl hydrazide and 1,3,4-oxadiazole derivatives (JL1-JL4) were characterized by 1H NMR, 13C NMR, DEPT, HMQC, HMBC, and IR spectroscopic. The antioxidant activity of carboxyl hydrazide and 1,3,4-oxadiazole derivatives were evaluated by using 2,2-diphenyl-2-picryhydrazyl hydrate (DDPH) radical scavenging assay where the carboxyl hydrazide and 1,3,4- oxadiazole showed weak antioxidant activity.
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